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PERSPECTIVES
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3351-3371
| Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery
Robert V. Talanian,
Kenneth D. Brady, and
Vincent L. Cryns
[Full Article -
PDF] | |
3372-3376
Discovery of (2S)-1-(4-Amino-2,3,5- trimethylphenoxy)-3-{4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl}-2- propanol Dimethanesulfonate (SUN N8075): A Dual Na+ and Ca2+ Channel Blocker with Antioxidant Activity
Hirokazu Annoura,
Kyoko Nakanishi,
Tetsuya Toba,
Naohiro Takemoto,
Seiichi Imajo,
Atsuko Miyajima,
Yoshiko Tamura-Horikawa, and
Shigeki Tamura
[Full Article -
PDF]
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ARTICLES
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3377-3385
Two Crystal Structures of Human Neutrophil Collagenase, One Complexed with a Primed- and the Other with an Unprimed-Side Inhibitor: Implications for Drug Design
Enrico Gavuzzo,
Giorgio Pochetti,
Fernando Mazza,
Carlo Gallina,
Barbara Gorini,
Silvana D'Alessio,
Michael Pieper,
Harald Tschesche, and
Paul A. Tucker[Full Article -
PDF]
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3386-3399
Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors
Bruce D. Dorsey,
Colleen McDonough,
Stacey L. McDaniel,
Rhonda B. Levin,
Christina L. Newton,
Jacob M. Hoffman,
Paul L. Darke,
Joan A. Zugay-Murphy,
Emilio A. Emini,
William A. Schleif,
David B. Olsen,
Mark W. Stahlhut,
Carrie A. Rutkowski,
Lawrence C. Kuo,
Jiunn H. Lin,
I-W. Chen,
Stuart R. Michelson,
M. Katharine Holloway,
Joel R. Huff, and
Joseph P. Vacca[Full Article -
PDF]
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3400-3407
Synthesis and Biological Activity of a Novel 11a-Homo (Cyclohexyl) Prostaglandin
Peter G. Klimko,
Terry L. Davis,
Brenda W. Griffin, and
Najam A. Sharif[Full Article -
PDF]
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3408-3419
Subtype-Selective N-Methyl-D-Aspartate Receptor Antagonists: Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines
Jon L. Wright,
Tracy F. Gregory,
Suzanne R. Kesten,
Peter A. Boxer,
Kevin A. Serpa,
Leonard T. Meltzer, and
Lawrence D. Wise
, Stephen A. Espitia,
Christopher S. Konkoy,
Edward R. Whittemore, and
Richard M. Woodward[Full Article -
PDF]
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3420-3427
Structure-Activity Studies Including a  (CH2-NH) Scan of Peptide YY (PYY) Active Site, PYY(22-36), for Interaction with Rat Intestinal PYY Receptors: Development of Analogues with Potent in Vivo Activity in the Intestine
Ambikaipakan Balasubramaniam,
Zhiyong Tao,
Weixu Zhai,
Meiczyslawa Stein,
Sulaiman Sheriff,
William T. Chance,
Josef E. Fischer,
Peter E. Eden,
John E. Taylor,
Carson D. Liu,
David W. McFadden,
Thierry Voisin,
Claude Roze, and
Marc Laburthe[Full Article -
PDF]
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3428-3433
A New Class of Potential Chloroquine-Resistance Reversal Agents for Plasmodia: Syntheses and Biological Evaluation of 1-(3'-Diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines
Sanjay Batra,
Pratima Srivastava,
Kamal Roy,
V. C. Pandey, and
A. P. Bhaduri[Full Article -
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3434-3442
Difluoro Ketone Peptidomimetics Suggest a Large S1 Pocket for Alzheimer's  -Secretase: Implications for Inhibitor Design
Chad L. Moore,
Dartha D. Leatherwood,
Thekla S. Diehl,
Dennis J. Selkoe, and
Michael S. Wolfe[Full Article -
PDF]
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3443-3447
Privileged Molecules for Protein Binding Identified from NMR-Based Screening
Philip J. Hajduk,
Mark Bures,
Jens Praestgaard, and
Stephen W. Fesik[Full Article -
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BRIEF ARTICLES
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3448-3452
QSAR Based on Biological Microcalorimetry
Maria Luiza C. Montanari,
Anthony E. Beezer,
Carlos A. Montanari, and
Dorila Piló-Veloso[Full Article -
PDF]
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